Beer production should not only have good equipment, but also have a matching cleaning process, so as to ensure that the beer production process is not infected by miscellaneous bacteria, so as to improve the biological stability and taste stability of the finished beer. Small beer equipment manufacturers share the fermentation tank cleaning process. CIP cleaning process of fermentation tank, • rinse water until no bubble → 2. 0 ~ 4. 0% lye cycle cleaning for 30 minutes → Flushing to pH neutral → detoxification agent cycle sterilization for more than 10 minutes. According to the above theoretical analysis, the following CIP cleaning process can be designed :•(1)Alkali washing, pickling and detoxification; •(2)Alkali washing and disinfection; •(3)Pickling and disinfection; •(4)Acidic cleaning agent containing disinfectant.